Article
Maximum likelihood estimation of the heterogeneity of substitution rate among nucleotide sites.
Molecular biology and evolution - 1 Jul 1995
Gu X, Fu Y X, Li W H
Abstract excerpt
This paper presents a maximum likelihood approach to estimating the variation of substitution rate among nucleotide sites. We assume that the rate varies among sites according to an invariant+gamma distribution, which has two parameters: the gamma parameter alpha and the proportion of invariable sites theta. Theoretical treatments on three, four, and five sequences have been conducted, and computer program have...
Topics
- Computer Simulation
- DNA
- Genetic Variation
- Likelihood Functions
- Models, Genetic
- Nucleotides
- RNA, Ribosomal