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Article

Maximum likelihood estimation of the heterogeneity of substitution rate among nucleotide sites.

Molecular biology and evolution - 1 Jul 1995

Gu X, Fu Y X, Li W H

Abstract excerpt

This paper presents a maximum likelihood approach to estimating the variation of substitution rate among nucleotide sites. We assume that the rate varies among sites according to an invariant+gamma distribution, which has two parameters: the gamma parameter alpha and the proportion of invariable sites theta. Theoretical treatments on three, four, and five sequences have been conducted, and computer program have...

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PMID: 7659011
DOI: 10.1093/oxfordjournals.molbev.a040235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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