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Article

Approximate methods for estimating the pattern of nucleotide substitution and the variation of substitution rates among sites.

Molecular biology and evolution - 1 May 1996

Yang Z, Kumar S

Abstract excerpt

We propose two approximate methods (one based on parsimony and one on pairwise sequence comparison) for estimating the pattern of nucleotide substitution and a parsimony-based method for estimating the gamma parameter for variable substitution rates among sites. The matrix of substitution rates that represents the substitution pattern can be recovered through its relationship with the observable matrix of site...

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PMID: 8676739
DOI: 10.1093/oxfordjournals.molbev.a025625

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