Approximate methods for estimating the pattern of nucleotide substitution and the variation of substitution rates among sites.

doi:10.1093/oxfordjournals.molbev.a025625

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Article

Approximate methods for estimating the pattern of nucleotide substitution and the variation of substitution rates among sites.

Molecular biology and evolution - 1 May 1996

Yang Z, Kumar S

Abstract excerpt

We propose two approximate methods (one based on parsimony and one on pairwise sequence comparison) for estimating the pattern of nucleotide substitution and a parsimony-based method for estimating the gamma parameter for variable substitution rates among sites. The matrix of substitution rates t...

Topics

Algorithms
Animals
Cytochrome b Group
DNA
DNA, Mitochondrial
Evolution, Molecular
Genetic Variation
Humans
Likelihood Functions
Models, Genetic
Models, Statistical
RNA, Ribosomal, 16S

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