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Article

Vasopressin and angiotensin II are absent but spontaneously reappear in solitary hypothalamic neurons of the homozygous Brattleboro rat.

Neuroscience letters - 24 Jun 1991

van Leeuwen F W, vd Beek E M, van Heerikhuize J J, Sluiter A A, Felix D, Imboden H

Abstract excerpt

The homozygous Brattleboro rat (di/di) synthesizes a vasopressin (VP) precursor with a different C-terminus, which is not packaged in granules. In addition, the expression of a coexisting peptide, angiotensin II (Ang II), is disturbed. During postnatal life a small but increasing number of solitary post-mitotic hypothalamic neurons of the di/di rat undergoes a switch to a genuine heterozygous phenotype. Here we...

Topics

Angiotensin II
Animals
Female
Gene Expression
Glycopeptides
Homozygote
Hypothalamus
Male
Neurons
Phenotype
Rats
Rats, Brattleboro

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vasopressins

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Identifiers

PMID: 1881632
DOI: 10.1016/0304-3940(91)90795-u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1881632-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Vasopressin and angiotensin II are absent but spontaneously reappear in solitary hypothalamic neurons of the homozygous Brattleboro rat.PMID 1881632Read ↗

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Immunocytochemical evidence for the presence of vasopressin in intermediate sized neurosecretory granules of solitary neurohypophyseal terminals in the homozygous Brattleboro rat.Semantic proximity Read ↗

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The magnocellular neurons of the hypothalamo-neurohypophyseal system display remarkable neuropeptidergic phenotypes leading to novel insights in neuronal cell biology.Semantic proximity Read ↗

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