Article
Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats.
Nature - 1 Jan 2000
Schmale H, Richter D
Abstract excerpt
In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Deletion
- Diabetes Insipidus
- Genes
- Hypothalamus
- Liver
- Mutation
- Nucleic Acid Hybridization
- Protein Biosynthesis
- RNA, Messenger
- Rabbits