Article
<i>Candida albicans</i>Secreted Aspartyl Proteinases in Virulence and Pathogenesis
1 Sept 2003
Abstract excerpt
Candida albicans is the most common fungal pathogen of humans and has developed an extensive repertoire of putative virulence mechanisms that allows successful colonization and infection of the host under suitable predisposing conditions. Extracellular proteolytic activity plays a central role in Candida pathogenicity and is produced by a family of 10 secreted aspartyl proteinases (Sap proteins). Although the...