Article
Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis.
PloS one - 1 Jan 2012
Puri Sumant, Kumar Rohitashw, Chadha Sonia, Tati Swetha, Conti Heather R, Hube Bernhard, Cullen Paul J, Edgerton Mira
Abstract excerpt
Perception of external stimuli and generation of an appropriate response are crucial for host colonization by pathogens. In pathogenic fungi, mitogen activated protein kinase (MAPK) pathways regulate dimorphism, biofilm/mat formation, and virulence. Signaling mucins, characterized by a heavily glycosylated extracellular domain, a transmembrane domain, and a small cytoplasmic domain, are known to regulate various...
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