Article
Expression of p53 predicts treatment failure in aggressive non-Hodgkin's lymphomas.
Leukemia & lymphoma - 1 Mar 1998
Navaratnam S, Williams G J, Rubinger M, Pettigrew N M, Mowat M R, Begleiter A, Johnston J B
Abstract excerpt
Approximately 50% of patients with aggressive non-Hodgkin's lymphomas (NHL) achieve a complete remission (CR) and cure with combination chemotherapy. The International Index is a useful clinical measure that predicts the patients' tolerance of therapy and likelihood of achieving CR, but it is not...
Topics
- Antineoplastic Combined Chemotherapy Protocols
- Cyclophosphamide
- Doxorubicin
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Lymphoma, Non-Hodgkin
- Male
- Middle Aged
- Mutation
- Prednisone
- Prognosis
- Retrospective Studies
- Treatment Outcome
- Vincristine