Article
Expression of p53 predicts treatment failure in aggressive non-Hodgkin's lymphomas.
Leukemia & lymphoma - 1 Mar 1998
Navaratnam S, Williams G J, Rubinger M, Pettigrew N M, Mowat M R, Begleiter A, Johnston J B
Abstract excerpt
Approximately 50% of patients with aggressive non-Hodgkin's lymphomas (NHL) achieve a complete remission (CR) and cure with combination chemotherapy. The International Index is a useful clinical measure that predicts the patients' tolerance of therapy and likelihood of achieving CR, but it is not a direct measure of chemosensitivity. In this study we have investigated the predictive value of the tumor suppressor...
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