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Article

The impact of P53 and P21(waf1) expression on the survival of patients with the germinal center phenotype of diffuse large B-cell lymphoma.

Haematologica - 1 May 2006

Visco Carlo, Canal Fabio, Parolini Claudia, Andreoli Annalisa, Ambrosetti Achille, Krampera Mauro, Lestani Maurizio, Pizzolo Giovanni, Chilosi Marco

Abstract excerpt

Immunohistochemically detected over-expression of P53-related protein (P53+++) and absence of P21(waf1) expression (P21-) correspond to loss of function of the P53-gene in diffuse large B-cell lymphoma (DLBCL) patients. Using immunohistochemistry we examined 80 patients with DLBCL and found that 23% had the P53+++/P21- phenotype while 51% had a germinal center (GC) pattern. Both the P53+++/P21- phenotype and the...

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PMID: 16670073

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