Article
X-ray- and ultraviolet-radiation-induced mutations in Muta mouse.
Radiation research - 1 Aug 1997
Ono T, Ikehata H, Hosoi Y, Shung B S, Kurishita A, Wang X, Yamamoto K, Suzuki T, Sofuni T
Abstract excerpt
To evaluate the usefulness of the transgenic Muta mouse for investigating radiation-induced mutations in vivo, we have examined the effects of whole-body X irradiation and compared them to the effects of ultraviolet light. The spontaneous mutation frequencies in young adults were about 7 x 10(-5) in the spleen, liver and skin. The mutation frequencies 1 week after a lethal dose of X radiation (8 Gy) were 3.2, 2.6...
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