Article
Cells that register logical relationships among proteins.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 1997
Xu C W, Mendelsohn A R, Brent R
Abstract excerpt
Two-hybrid methods have augmented the classical genetic techniques biologists use to assign function to genes. Here, we describe construction of a two-bait interaction trap that uses yeast cells to register more complex protein relationships than those detected in existing two-hybrid systems. We show that such cells can identify bridge or connecting proteins and peptide aptamers that discriminate between closely...
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