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Article

Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor.

The Journal of biological chemistry - 19 Apr 1996

Gallagher M J, Huang H, Pritchett D B, Lynch D R

Abstract excerpt

Ifenprodil is an atypical noncompetitive modulator of the N-methyl-D-aspartate (NMDA) receptor (NR) which demonstrates a 140-fold preference for NR2B over NR2A subunits, although the molecular basis for this subunit specificity is unknown. We have made chimeric receptors by fusing the murine forms of NR2A (epsilon 1) and NR2B (epsilon 2) to localize the high affinity determinants of ifenprodil inhibition on the...

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PMID: 8621635
DOI: 10.1074/jbc.271.16.9603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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