Article
Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor.
The Journal of biological chemistry - 19 Apr 1996
Gallagher M J, Huang H, Pritchett D B, Lynch D R
Abstract excerpt
Ifenprodil is an atypical noncompetitive modulator of the N-methyl-D-aspartate (NMDA) receptor (NR) which demonstrates a 140-fold preference for NR2B over NR2A subunits, although the molecular basis for this subunit specificity is unknown. We have made chimeric receptors by fusing the murine form...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Arginine
- Base Sequence
- Binding Sites
- Cell Line
- Cloning, Molecular
- DNA Primers
- Dizocilpine Maleate
- Excitatory Amino Acid Antagonists
- Genetic Variation
- Humans
- Kidney
- Kinetics
- Macromolecular Substances
- Mice
- Molecular Sequence Data