Article
Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence.
Pharmacogenetics - 1 Oct 1997
Tyndale R F, Droll K P, Sellers E M
Abstract excerpt
Oral opiates (e.g. codeine, oxycodone, and hydrocodone) are metabolized by cytochrome CYP2D6 to metabolites of increased activity (e.g. morphine, oxymorphone and hydromorphone). CYP2D6 is genetically polymorphic, 4-10% of Caucasians lack CYP2D6 activity (poor metabolizers) due to inheritance of t...
Topics
- Administration, Oral
- Adult
- Analgesics, Opioid
- Cytochrome P-450 CYP2D6
- Female
- Genotype
- Humans
- Male
- Opioid-Related Disorders
- Phenotype