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Article

Life-threatening adverse events following therapeutic opioid administration in adults: is pharmacogenetic analysis useful?

Pain research & management - 1 Jan 2000

Madadi Parvaz, Sistonen Johanna, Silverman Gregory, Gladdy Rebecca, Ross Colin J, Carleton Bruce C, Carvalho Jose C, Hayden Michael R, Koren Gideon

Abstract excerpt

BACKGROUND: Systemic approaches are needed to understand how variations in the genes associated with opioid pharmacokinetics and response can be used to predict patient outcome. The application of pharmacogenetic analysis to two cases of life-threatening opioid-induced respiratory depression is presented. The usefulness of genotyping in the context of these cases is discussed. METHODS: A panel of 20 functional...

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Share to Analgesics, Opioid
Share to ABCB1 gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 23748253
DOI: 10.1155/2013/518012
PMCID: PMC3673930

Genes

ABCB1
COMT
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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