Article
Influence of CYP2D6 Genetics on Opioid Kinetics, Metabolism and Response.
2005-03-01
Abstract excerpt
Pharmacogenetics does seem to play a key role in the use of so-called weak opioids. It has been shown for codeine, dihydrocodeine, oxycodone and hydrocodone, that their O-demethylation in the 3-position results in metabolites which have much stronger mu-receptor binding. These opioids may therefore exert their pharmacological actions predominantly through their O-demethylated metabolites. However, this metabolic s...
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Identifiers and source
- Literature Corpus work
- a9bb251a-bc73-54b5-921a-17fa6cb57c2f
- DOI
- 10.2174/1570160053175018