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Article

Cytochrome P450 2D6 polymorphisms and predicted opioid metabolism in African American children with sickle cell disease.

Journal of pediatric hematology/oncology - 1 Oct 2013

Yee Marianne M, Josephson Cassandra, Hill Charles E, Harrington Rosiland, Castillejo Marta-Inés, Ramjit Ruan, Osunkwo Ifeyinwa

Abstract excerpt

The opioid medications codeine and hydrocodone, commonly prescribed in sickle cell disease (SCD), require metabolic conversion by cytochrome P450 2D6 (CYP2D6) to morphine and hydromorphone, respectively, to exert their analgesic effects. The CYP2D6 gene is highly polymorphic, with variant alleles that result in decreased, absent, or ultrarapid enzyme activity. Seventy-five children with SCD were tested for CYP2D6...

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Share to Adolescent
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Anemia, Sickle Cell

Share to Black or African American

Share to Cytochrome P-450 CYP2D6

Share to Gene Frequency

Share to Polymorphism, Genetic

Source

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Identifiers

PMID: 23619115
DOI: 10.1097/MPH.0b013e31828e52d2
PMCID: PMC3762954

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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