Changes in expression and organization of smooth-muscle-specific alpha-actin during fibronectin-mediated modulation of arterial smooth muscle cell phenotype.

doi:10.1111/j.1432-0436.1990.tb00621.x

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Article

Changes in expression and organization of smooth-muscle-specific alpha-actin during fibronectin-mediated modulation of arterial smooth muscle cell phenotype.

Differentiation; research in biological diversity - 1 Sept 1990

Hedin U, Sjölund M, Hultgårdh-Nilsson A, Thyberg J

Abstract excerpt

The spreading of freshly isolated arterial smooth muscle cells on a substrate of fibronectin is mediated by an integrin receptor on the cell surface. It is associated with organization of actin filaments in stress fibers and marked changes in cell morphology and function, collectively referred to as a transition from a contractile to a synthetic phenotype. To study further how extracellular matrix components...

Topics

Actins
Amino Acid Sequence
Animals
Antigens, Differentiation
Aorta
Cells, Cultured
Electrophoresis, Polyacrylamide Gel
Fibronectins
Immunoblotting
Integrins
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Fluorescence

Molecular Sequence Data

Muscle, Smooth, Vascular

Nucleic Acid Hybridization

Phenotype

RNA

Rats

Source

Open in PubMed

Identifiers

PMID: 1703095
DOI: 10.1111/j.1432-0436.1990.tb00621.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1703095-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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