Altered ParA partition proteins of plasmid P1 act via the partition site to block plasmid propagation.

doi:10.1046/j.1365-2958.1997.4761842.x

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Article

Altered ParA partition proteins of plasmid P1 act via the partition site to block plasmid propagation.

Molecular microbiology - 1 Sept 1997

Youngren B, Austin S

Abstract excerpt

The partition system of the P1 plasmid, P1par, consists of the ParA and ParB proteins and a cis-acting site, parS. It is responsible for the orderly segregation of plasmid copies to daughter cells. Plasmids with null mutations in parA or parB replicate normally, but missegregate. ParB binds specifically to the parS site, but the role of ParA and its ATPase activity in partition is unclear. We describe a novel...

Topics

Bacterial Proteins
Binding Sites
Culture Media
Operon
Phenotype
Plasmids
Point Mutation

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Identifiers

PMID: 9350860
DOI: 10.1046/j.1365-2958.1997.4761842.x

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