Article
Dissection of the ATPase active site of P1 ParA reveals multiple active forms essential for plasmid partition.
The Journal of biological chemistry - 14 Jun 2013
Vecchiarelli Anthony G, Havey James C, Ing Lori L, Wong Erin O Y, Waples William G, Funnell Barbara E
Abstract excerpt
The segregation, or partition, of bacterial plasmids is driven by the action of plasmid-encoded partition ATPases, which work to position plasmids inside the cell. The most common type of partition ATPase, generally called ParA, is represented by the P1 plasmid ParA protein. ParA interacts with P1 ParB (the site-specific DNA binding protein that recognizes the parS partition site), and interacts with the...
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