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Article

The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 1999

Jin Y, Jorgensen E, Hartwieg E, Horvitz H R

Abstract excerpt

The neurotransmitter GABA has been proposed to play a role during nervous system development. We show that the Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase (GAD), the GABA biosynthetic enzyme. unc-25 is expressed specifically in GABAergic neurons. Null mutations in unc-2...

Topics

Amino Acid Sequence
Animals
Axons
Caenorhabditis elegans
Gene Expression Regulation, Enzymologic
Glutamate Decarboxylase
Molecular Sequence Data
Mutation
Neuromuscular Junction
Phenotype
Synapses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Synaptic Transmission

gamma-Aminobutyric Acid

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Identifiers

PMID: 9880574
PMCID: PMC6782196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9880574-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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