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Article

The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 1999

Jin Y, Jorgensen E, Hartwieg E, Horvitz H R

Abstract excerpt

The neurotransmitter GABA has been proposed to play a role during nervous system development. We show that the Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase (GAD), the GABA biosynthetic enzyme. unc-25 is expressed specifically in GABAergic neurons. Null mutations in unc-25 eliminate the UNC-25 protein or alter amino acids conserved in all known GADs, result in a complete lack of GABA, and...

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PMID: 9880574
PMCID: PMC6782196

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