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Article

Role of androgens in testicular tumor development in inhibin-deficient mice.

Endocrinology - 1 Nov 1997

Shou W, Woodruff T K, Matzuk M M

Abstract excerpt

To understand gonadal tumor development, we have previously created a mouse model in which mice deficient in the inhibins develop gonadal sex cord-stromal tumors with essentially 100% penetrance. These tumors develop as early as 4 weeks of age and cause cancer cachexia-like symptoms and subsequen...

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Source

Identifiers

PMID: 9348231
DOI: 10.1210/endo.138.11.5499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9348231-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of androgens in testicular tumor development in inhibin-deficient mice.PMID 9348231Read ↗

Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.Semantic proximity Read ↗

Cyclin D2 and p27 Are Tissue-Specific Regulators of Tumorigenesis in Inhibin α Knockout MiceSemantic proximity Read ↗

Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis.Semantic proximity Read ↗

Transgenic mouse models for tumor suppressor genes.Semantic proximity Read ↗

Genetic Removal of Smad3 from Inhibin-Null Mice Attenuates Tumor Progression by Uncoupling Extracellular Mitogenic Signals from the Cell Cycle MachinerySemantic proximity Read ↗

Normal reproductive function in InhBP/p120-deficient mice.Semantic proximity Read ↗

Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.Semantic proximity Read ↗

ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function.Semantic proximity Read ↗

Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.Semantic proximity Read ↗

Inhibin-A Antagonizes TGFβ2 Signaling by Down-Regulating Cell Surface Expression of the TGFβ Coreceptor BetaglycanSemantic proximity Read ↗

Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction.Semantic proximity Read ↗

Interrelationship of Growth Differentiation Factor 9 and Inhibin in Early Folliculogenesis and Ovarian Tumorigenesis in MiceSemantic proximity Read ↗

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