Article
Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 2003
Burns Kathleen H, Agno Julio E, Chen Lei, Haupt Bisong, Ogbonna Samuel C, Korach Kenneth S, Matzuk Martin M
Abstract excerpt
Sex steroids control cellular phenotypes by binding to receptor proteins that in turn regulate downstream gene expression. They are important tropic factors in hormonally responsive tissues and have been implicated in the pathogenesis of both benign proliferations and malignancies at some of these sites. Knockout mice lacking inhibins, alpha:beta heterodimeric peptide hormones of the TGFbeta superfamily, develop...
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