Article
Expression of IFN-gamma, IL-4, and TGF-beta in multiple sclerosis in relation to HLA-Dw2 phenotype and stage of disease.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Nov 1995
Söderström M, Hillert J, Link J, Navikas V, Fredrikson S, Link H
Abstract excerpt
Multiple sclerosis (MS) is associated with upregulation of both proinflammatory (interferon-gamma, IFN-gamma) and immunosuppressive (transforming growth factor-beta, TGF-beta) cytokines. To examine a possible relation between the MS-related HLA haplotype Dw2 and cytokine profiles, we used in situ...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Cytokines
- Disease Progression
- Female
- Gene Expression
- HLA-D Antigens
- Humans
- In Situ Hybridization
- Interferon-gamma
- Interleukin-4
- Leukocytes, Mononuclear
- Male
- Middle Aged
- Multiple Sclerosis
- Myelin Sheath