Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of cell type-specific responses in IFN-β therapy of multiple sclerosis

21 Nov 2011

Abstract excerpt

The mechanism of IFN-β therapy in relapsing-remitting multiple sclerosis (RRMS) is not well understood, but induction of apoptosis in specific leukocyte subsets is likely to be important. Enhanced expression of TNFSF10 or TNF-related apoptosis-inducing ligand (TRAIL) mRNA in unseparated leukocytes has been put forward as a therapeutic response marker, but it is unclear which leukocyte subsets express TRAIL. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to Immune Response and Inflammation
Share to Multiple Sclerosis Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22106296
DOI: 10.1073/pnas.1117347108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of cell type-specific responses in IFN-β therapy of multiple sclerosisPMID 22106296Read ↗

Interferon-Beta Induces Distinct Gene Expression Response Patterns in Human Monocytes versus T cellsSemantic proximity Read ↗

Complex immunomodulatory effects of interferon‐β in multiple sclerosis include the upregulation of T helper 1‐associated marker genesSemantic proximity Read ↗

Baseline Gene Expression Signatures in Monocytes from Multiple Sclerosis Patients Treated with Interferon-betaSemantic proximity Read ↗

Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cellsSemantic proximity Read ↗

Type I Interferon regulates cytokine-delayed neutrophil apoptosis, reactive oxygen species production and chemokine expression via activation of p38 MAPKSemantic proximity Read ↗

Differential Responses to IFN-α Subtypes in Human T Cells and Dendritic CellsSemantic proximity Read ↗

TRAIL gene expression analysis in multiple sclerosis patients.Semantic proximity Read ↗

Pharmacogenomics of Interferon-ß Therapy in Multiple Sclerosis: Baseline IFN Signature Determines Pharmacological Differences between PatientsSemantic proximity Read ↗

Elevated type I interferon-like activity in a subset of multiple sclerosis patients: molecular basis and clinical relevanceSemantic proximity Read ↗

PML mediates IFN-α–induced apoptosis in myeloma by regulating TRAIL inductionSemantic proximity Read ↗

IFNβ-1b treatment leads to changes in the B cell subset and cytokine secretion profile in patients with relapsing-remitting multiple sclerosisSemantic proximity Read ↗

TRAILR1 (rs20576) and GRIA3 (rs12557782) are not associated with interferon-β response in multiple sclerosis patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.