Model-free linkage analysis using likelihoods.

Article

Model-free linkage analysis using likelihoods.

American journal of human genetics - 1 Sept 1995

Curtis D, Sham P C

Abstract excerpt

Misspecification of transmission model parameters can produce artifactually negative lod scores at small recombination fractions and in multipoint analysis. To avoid this problem, we have tried to devise a test that aims to detect a genetic effect at a particular locus, rather than attempting to...

Topics

Chromosome Mapping
Genetic Linkage
Genotype
Humans
Likelihood Functions
Lod Score
Models, Genetic

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