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Article

Mutation and oxidative damage of mitochondrial DNA and defective turnover of mitochondria in human aging.

Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Oct 1997

Lee H C, Wei Y H

Abstract excerpt

Accumulation of somatic mutations in the mitochondrial DNA (mtDNA) is a major contributor to human aging and degenerative diseases. Rapid progress has been made in unraveling the molecular changes associated with aging. MtDNA mutations are likely early molecular events associated with human aging that may be responsible for the age-dependent decline in mitochondrial respiratory functions. Many types of mutations...

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PMID: 9343975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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