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Article

Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p.

Molecular and cellular biology - 1 Nov 1997

Pi H, Chien C T, Fields S

Abstract excerpt

In the yeast Saccharomyces cerevisiae, Ste12p induces transcription of pheromone-responsive genes by binding to a DNA sequence designated the pheromone response element. We generated a series of hybrid proteins of Ste12p with the DNA-binding and activation domains of the transcriptional activator Gal4p to define a pheromone induction domain of Ste12p sufficient to mediate pheromone-induced transcription by these...

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Identifiers

PMID: 9343403
DOI: 10.1128/MCB.17.11.6410
PMCID: PMC232493

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Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p.PMID 9343403Read ↗

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Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.Semantic proximity Read ↗

Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway.Semantic proximity Read ↗

Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway.Semantic proximity Read ↗

Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Far1.Semantic proximity Read ↗

Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast.Semantic proximity Read ↗

Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

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Cloning of the STE5 gene of Saccharomyces cerevisiae as a suppressor of the mating defect of cdc25 temperature-sensitive mutants.Semantic proximity Read ↗

Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction.Semantic proximity Read ↗

A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional binding between Gbeta and the LIM domain of Ste5 is required to activate the MEKK Ste11.Semantic proximity Read ↗

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