Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway.

doi:10.1093/genetics/143.1.103

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Article

Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway.

Genetics - 1 May 1996

Akada R, Kallal L, Johnson D I, Kurjan J

Abstract excerpt

The Saccharomyces cerevisiae G protein beta gamma dimer, Ste4p/Ste18p, acts downstream of the alpha subunit, Gpa1p, to activate the pheromone response pathway and therefore must interact with a downstream effector. Synthetic sterile mutants that exacerbate the phenotype of ste4-ts mutations were...

Topics

Adaptor Proteins, Signal Transducing
Carrier Proteins
Cell Cycle Proteins
Cloning, Molecular
Crosses, Genetic
Fungal Proteins
GTP-Binding Proteins
Genes, Fungal
Genotype
Intracellular Signaling Peptides and Proteins
MAP Kinase Kinase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Phenotype

Pheromones

Plasmids

Protein Serine-Threonine Kinases

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8722766
DOI: 10.1093/genetics/143.1.103
PMCID: PMC1207244

Genes

CDC42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8722766-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway.PMID 8722766Read ↗

Regulation of the yeast pheromone response pathway by G protein subunits.Semantic proximity Read ↗

Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p.Semantic proximity Read ↗

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.Semantic proximity Read ↗

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.Semantic proximity Read ↗

Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway.Semantic proximity Read ↗

The Leu-132 of the Ste4(Gbeta) subunit is essential for proper coupling of the G protein with the Ste2 alpha factor receptor during the mating pheromone response in yeast.Semantic proximity Read ↗

Biochemical and genetic analysis of dominant-negative mutations affecting a yeast G-protein gamma subunit.Semantic proximity Read ↗

Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Far1.Semantic proximity Read ↗

STE50, a novel gene required for activation of conjugation at an early step in mating in Saccharomyces cerevisiae.Semantic proximity Read ↗

Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase.Semantic proximity Read ↗

Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p.Semantic proximity Read ↗

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