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Article

Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae.

Molecular microbiology - 1 May 1996

Xu G, Jansen G, Thomas D Y, Hollenberg C P, Ramezani Rad M

Abstract excerpt

In the yeast Saccharomyces cerevisiae, the heterotrimeric G protein transduces the mating pheromone signal from a cell-surface receptor. Free G beta gamma then activates a mitogen-activated protein (MAP) kinase cascade. STE50 has been shown to be involved in this pheromone signal-transduction pathway. In this study, we present a functional characterization of Ste50p, a protein that is required to sustain the...

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Source

Identifiers

PMID: 8793874
DOI: 10.1111/j.1365-2958.1996.tb02516.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae.PMID 8793874Read ↗

Ste50p is involved in regulating filamentous growth in the yeast Saccharomyces cerevisiae and associates with Ste11p.Semantic proximity Read ↗

Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p.Semantic proximity Read ↗

Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway.Semantic proximity Read ↗

STE50, a novel gene required for activation of conjugation at an early step in mating in Saccharomyces cerevisiae.Semantic proximity Read ↗

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.Semantic proximity Read ↗

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.Semantic proximity Read ↗

The RA domain of Ste50 adaptor protein is required for delivery of Ste11 to the plasma membrane in the filamentous growth signaling pathway of the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The Leu-132 of the Ste4(Gbeta) subunit is essential for proper coupling of the G protein with the Ste2 alpha factor receptor during the mating pheromone response in yeast.Semantic proximity Read ↗

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway.Semantic proximity Read ↗

Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway.Semantic proximity Read ↗

Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulation of the yeast pheromone response pathway by G protein subunits.Semantic proximity Read ↗

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