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In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine.

Antimicrobial agents and chemotherapy - 1 Sept 2005

Hammond Jennifer L, Parikh Urvi M, Koontz Dianna L, Schlueter-Wirtz Susan, Chu Chung K, Bazmi Hengameh Z, Schinazi Raymond F, Mellors John W

Abstract excerpt

Serial passage of human immunodeficiency virus type 1 in MT-2 cells in increasing concentrations of the d- and l-enantiomers of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine (d4FC) resulted in the selection of viral variants with reverse transcriptase substitutions M184I or M184V for l-d4FC and I63L, K65R, K70N, K70E, or R172K for d-d4FC. Phenotypic analysis of site-directed mutants defined the role of...

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Identifiers

PMID: 16127074
DOI: 10.1128/AAC.49.9.3930-3932.2005
PMCID: PMC1195387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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