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Article

HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans.

Genetics - 1 Feb 2018

Agarwal Ipsita, Farnow Cassandra, Jiang Joshua, Kim Kyung-Sik, Leet Donna E, Solomon Ruth Z, Hale Valerie A, Goutte Caroline

Abstract excerpt

Functionally redundant genes present a puzzle as to their evolutionary preservation, and offer an interesting opportunity for molecular specialization. In Caenorhabditis elegans, either one of two presenilin genes (sel-12 or hop-1) facilitate Notch activation, providing the catalytic subunit for the γ secretase proteolytic enzyme complex. For all known Notch signaling events, sel-12 can mediate Notch activation,...

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Identifiers

PMID: 29242286
DOI: 10.1534/genetics.117.300605
PMCID: PMC5788535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans.PMID 29242286Read ↗

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