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Article

Loss of DNA Mismatch Repair: Effects on the Rate of Mutation to Drug Resistance

15 Oct 1997

Abstract excerpt

BACKGROUND: The loss of the ability of cells to repair mismatches in double-stranded DNA is a common finding in human tumors. This defect results in genomic instability and in increased resistance to several of the drugs used in cancer chemotherapy. The human colon cancer cell line HCT116 is deficient in DNA mismatch repair (MMR) because of a genetic defect in the hMLH1 gene, which is located on chromosome 3. In...

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PMID: 9337351
DOI: 10.1093/jnci/89.20.1537

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