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Article

DNA mismatch repair and p53 function are major determinants of the rate of development of cisplatin resistance

1 May 2006

Abstract excerpt

As opposed to factors that control sensitivity to the acute cytotoxic effect of cisplatin, little is known about the factors that determine the rate at which resistance develops. This study examined how loss of p53 or DNA mismatch repair (MMR) function affected the rate of development of resistance to cisplatin in human colon carcinoma cells during sequential cycles of cisplatin exposure that mimic the way the...

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PMID: 16731756
DOI: 10.1158/1535-7163.mct-05-0491

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