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Article

Roles of the DNA mismatch repair genes in colorectal tumorigenesis.

International journal of cancer - 20 Feb 1996

Boland C R

Abstract excerpt

A rapid increase in our understanding of the basic mechanisms involved in the genesis of colorectal cancer has occurred. Important factors include the activation of oncogenes, the inactivation of tumor suppressor genes and the inactivation of DNA repair systems. Hereditary non-polyposis colorectal cancer (HNPCC) has been linked to germ-line mutations that inactivate one allele of a DNA mismatch repair gene, which...

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PMID: 8600059
DOI: 10.1002/(SICI)1097-0215(19960220)69:1<47::AID-IJC11>3.0.CO;2-H

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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