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Article

Suppressors of the ndc10-2 mutation: a role for the ubiquitin system in Saccharomyces cerevisiae kinetochore function.

Genetics - 1 Oct 1997

Kopski K M, Huffaker T C

Abstract excerpt

We have isolated a new conditional-lethal mutation, ndc10-2, in the NDC10/CBF2/CTF14 gene that encodes the 110-kD subunit of the Saccharomyces cerevisiae CBF3 kinetochore complex. At the restrictive temperature of 37 degrees, ndc10-2 cells are able to assemble anaphase spindles, but fail to segregate their DNA, consistent with a defect in kinetochore function. To identify other factors that play a role in...

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Identifiers

PMID: 9335582
DOI: 10.1093/genetics/147.2.409
PMCID: PMC1208167

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