Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme.

doi:10.1128/MCB.15.9.4835

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Article

Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme.

Molecular and cellular biology - 1 Sept 1995

Yoon H J, Carbon J

Abstract excerpt

CBF2/NDC10/CTF14 encodes the 110-kDa subunit of CBF3, a key component of the yeast centromere/kinetochore. Overexpression of yeast CDC34 specifically suppresses the temperature-sensitive growth phenotype of the ndc10-1 mutation. Mutations in CDC34, which specifies a ubiquitin-conjugating enzyme, arrest yeast cells in the G1 phase of the cell cycle, with no intact spindles formed (M. G. Goebl, J. Yochem, S....

Topics

Anaphase-Promoting Complex-Cyclosome
DNA-Binding Proteins
Fungal Proteins
Gene Dosage
Kinetochores
Ligases
Mutation
Protein Processing, Post-Translational
Recombinant Proteins
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae Proteins

Suppression, Genetic

Ubiquitin-Conjugating Enzymes

Ubiquitin-Protein Ligase Complexes

Ubiquitin-Protein Ligases

Ubiquitins

Source

Open in PubMed Open full text

Identifiers

PMID: 7651401
DOI: 10.1128/MCB.15.9.4835
PMCID: PMC230728

Genes

CDC34

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7651401-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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