Article
Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b.
Journal of medical virology - 1 Oct 1997
Hofgärtner W T, Polyak S J, Sullivan D G, Carithers R L, Gretch D R
Abstract excerpt
Previous studies from Japan have described an association between a conserved sequence within the hepatitis C virus (HCV) genome and resistance to interferon (IFN) therapy for patients infected with HCV genotype 1b [Enomoto et al. (1995): Journal of Clinical Investigation 96: 224-230; Enomoto et al. (1996): New England Journal of Medicine 334:77-81]. The present study examines amino acid sequences surrounding the...
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