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Article

Does sequencing the PKRBD of hepatitis C virus NS5A predict therapeutic response to combination therapy in an Australian population?

Journal of gastroenterology and hepatology - 1 May 2004

Macquillan Gerry C, Niu Xianwa, Speers David, English Suzanne, Garas George, Harnett Gerry B, Reed William D, Allan Jane E, Jeffrey Gary P

Abstract excerpt

UNLABELLED: Abstract Background and Aim: The presence of four or more amino acid substitutions within the interferon sensitivity determining region (ISDR) of the hepatitis C virus (HCV) genotype 1b NS5A gene determines sensitivity to interferon (IFN) monotherapy in Japanese patients. Resistance of HCV genotype 1 to IFN-alpha has been attributed to the functional inhibition of a RNA dependent protein kinase (PKR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interferon-alpha

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Source

Identifiers

PMID: 15086599
DOI: 10.1111/j.1440-1746.2003.03319.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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