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Article

Distinct activities of the related protein kinases Cdk1 and Ime2.

Biochimica et biophysica acta - 1 Mar 2007

Sawarynski Kara E, Kaplun Alexander, Tzivion Guri, Brush George S

Abstract excerpt

In budding yeast, commitment to DNA replication during the normal cell cycle requires degradation of the cyclin-dependent kinase (CDK) inhibitor Sic1. The G1 cyclin-CDK complexes Cln1-Cdk1 and Cln2-Cdk1 initiate the process of Sic1 removal by directly catalyzing Sic1 phosphorylation at multiple sites. Commitment to DNA replication during meiosis also appears to require Sic1 degradation, but the G1 cyclin-CDK...

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Identifiers

PMID: 17137646
DOI: 10.1016/j.bbamcr.2006.10.003
PMCID: PMC3814016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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