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A Global Gene Pool for High‐Level Cephalosporin Resistance in Commensal<i>Streptococcus</i>Species and<i>Streptococcus pneumoniae</i>

1 Oct 1997

Abstract excerpt

Highly penicillin- and cephalosporin-resistant Streptococcus mitis and Streptococcus oralis were isolated in Spain, Hungary, and Berlin. With chromosomal DNA of these strains, resistant transformants of Streptococcus pneumoniae were obtained that expressed low-affinity variants of penicillin-binding proteins (PBPs) 2x, 1a, 2a, and 2b in different combinations, depending on the selective conditions. The...

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PMID: 9333159
DOI: 10.1086/516532

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