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Penicillin-Binding Proteins as Resistance Determinants in Clinical Isolates of Streptococcus pneumoniae

1 Jun 1996

Abstract excerpt

Altered penicillin-binding proteins (PBPs) with reduced affinity for penicillin are encoded by mosaic genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Generally, members of one bacterial clone contain the same mosaic gene. We report here on a serotype 19A clone of penicillin- and multiple-resistant S. pneumoniae prevalent in Hungary, members of which are exceptionally diverse in terms...

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PMID: 9158756
DOI: 10.1089/mdr.1996.2.177

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