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An Important Site in PBP2x of Penicillin-Resistant Clinical Isolates of <i>Streptococcus pneumoniae</i> : Mutational Analysis of Thr338

16 Dec 2008

Abstract excerpt

Penicillin-binding protein 2x (PBP2x) of Streptococcus pneumoniae represents a primary resistance determinant for beta-lactams, and low-affinity PBP2x variants can easily be selected with cefotaxime. Penicillin-resistant clinical isolates of S. pneumoniae frequently contain in their mosaic PBP2x the mutation T338A adjacent to the active site S337, and T338P as well as T338G substitutions are also known....

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PMID: 19075056
DOI: 10.1128/aac.01107-08

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