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Article

High-resolution HLA typing for the DRB3/4/5 genes by sequence-based typing.

Tissue antigens - 1 Sept 1997

Voorter C E, de Bruyn-Geraets D, van den Berg-Loonen E M

Abstract excerpt

The high degree of polymorphism of the HLA genes at the nucleotide sequence level has proven sequence-based typing a major typing strategy. For DRB1 the allelic variability is predominantly present in the second exon and by DNA sequencing of exon 2 all hitherto known DRB1 alleles can be detected. For the associated genes DRB3, DRB4 and DRB5 the situation is slightly different. Allelic differences are not limited...

Topics

Alleles
Base Sequence
HLA-DR Antigens
HLA-DRB3 Chains
HLA-DRB4 Chains
HLA-DRB5 Chains
Histocompatibility Testing
Humans
Molecular Sequence Data
Polymorphism, Genetic
Sequence Analysis, DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9331951
DOI: 10.1111/j.1399-0039.1997.tb02872.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9331951-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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