Article
High-resolution HLA typing for the DRB3/4/5 genes by sequence-based typing.
Tissue antigens - 1 Sept 1997
Voorter C E, de Bruyn-Geraets D, van den Berg-Loonen E M
Abstract excerpt
The high degree of polymorphism of the HLA genes at the nucleotide sequence level has proven sequence-based typing a major typing strategy. For DRB1 the allelic variability is predominantly present in the second exon and by DNA sequencing of exon 2 all hitherto known DRB1 alleles can be detected. For the associated genes DRB3, DRB4 and DRB5 the situation is slightly different. Allelic differences are not limited...
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