Article
Characterization of a new HLA-DRB3 allele, DRB3*0217, by direct sequencing.
Tissue antigens - 1 Aug 2002
Frison S, Longhi E, Poli F, Espadas de Arias A, Scalamogna M
Abstract excerpt
We report the identification of a novel DRB3*02 using sequence-based typing (SBT). This new allele, officially named DRB3*0217, was detected while performing HLA high resolution typing of a bone marrow recipient and his siblings. DNA sequencing demonstrated the presence of a nucleotide substitution in exon 2 at position 199 where a C was substituted by a T. This point mutation at codon 67 (CTC-->TTC) has resulted...
Topics
- Alleles
- Amino Acid Substitution
- Base Sequence
- HLA-DR Antigens
- HLA-DRB3 Chains
- Humans
- Male
- Molecular Sequence Data
- Point Mutation