Article
Expression and mutation analyses of MKK4, a candidate tumour suppressor gene encoded by chromosome 17p, in human gastric adenocarcinoma.
European journal of cancer (Oxford, England : 1990) - 1 Oct 2002
Chae K-S, Ryu B-K, Lee M-G, Byun D-S, Chi S-G
Abstract excerpt
Homozygous deletion or somatic mutations of mitogen-activated protein kinase kinase 4 (MKK4), a candidate tumour suppressor gene located at 17p11, have been observed in many types of human tumours. To explore the likelihood that MKK4 acts as a suppressor in gastric tumorigenesis, we examined the expression and mutation status of MKK4 in 144 gastric tissues and cell line specimens. Expression of the MKK4...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.