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Article

Expression and mutation analyses of MKK4, a candidate tumour suppressor gene encoded by chromosome 17p, in human gastric adenocarcinoma.

European journal of cancer (Oxford, England : 1990) - 1 Oct 2002

Chae K-S, Ryu B-K, Lee M-G, Byun D-S, Chi S-G

Abstract excerpt

Homozygous deletion or somatic mutations of mitogen-activated protein kinase kinase 4 (MKK4), a candidate tumour suppressor gene located at 17p11, have been observed in many types of human tumours. To explore the likelihood that MKK4 acts as a suppressor in gastric tumorigenesis, we examined the...

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Share to Chromosomes, Human, Pair 17
Share to Genes, Tumor Suppressor
Share to Loss of Heterozygosity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase 4

Share to Mitogen-Activated Protein Kinase Kinases

Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 12376211
DOI: 10.1016/s0959-8049(02)00147-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12376211-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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