Article
SMAD4 haploinsufficiency in small intestinal neuroendocrine tumors.
BMC cancer - 28 Jan 2021
Hofving Tobias, Elias Erik, Rehammar Anna, Inge Linda, Altiparmak Gülay, Persson Marta, Kristiansson Erik, Johansson Martin E, Nilsson Ola, Arvidsson Yvonne
Abstract excerpt
BACKGROUND: Patients with small intestinal neuroendocrine tumors (SINETs) frequently present with lymph node and liver metastases at the time of diagnosis, but the molecular changes that lead to the progression of these tumors are largely unknown. Sequencing studies have only identified recurrent point mutations at low frequencies with CDKN1B being the most common harboring heterozygous mutations in less than 10%...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.