Article
GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivo.
Neuroscience - 1 Dec 1997
Fritschy J M, Benke D, Johnson D K, Mohler H, Rudolph U
Abstract excerpt
The mechanisms governing the assembly of alpha-, beta- and gamma-subunits to form GABAA-receptors are poorly understood. Here, we report that the alpha-subunit is essential for receptor assembly. In mice homozygous for a deletion on chromosome 7 spanning the alpha 5- and gamma 3-subunit genes, zolpidem-insensitive benzodiazepine binding sites, corresponding to GABAA-receptors containing the alpha 5-subunit, were...
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