Article
GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivo.
Neuroscience - 1 Dec 1997
Fritschy J M, Benke D, Johnson D K, Mohler H, Rudolph U
Abstract excerpt
The mechanisms governing the assembly of alpha-, beta- and gamma-subunits to form GABAA-receptors are poorly understood. Here, we report that the alpha-subunit is essential for receptor assembly. In mice homozygous for a deletion on chromosome 7 spanning the alpha 5- and gamma 3-subunit genes, zo...
Topics
- Animals
- Autoradiography
- Brain Chemistry
- Chromosome Deletion
- Flumazenil
- GABA Modulators
- Hypnotics and Sedatives
- Immunohistochemistry
- Kinetics
- Membranes
- Mice
- Mutation
- Pyridines
- Radioligand Assay
- Receptors, GABA-A
- Zolpidem