Article
EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients.
Cancer research - 1 Sept 2005
Tang Ximing, Shigematsu Hisayuki, Bekele B Nebiyou, Roth Jack A, Minna John D, Hong Waun Ki, Gazdar Adi F, Wistuba Ignacio I
Abstract excerpt
To determine whether EGFR tyrosine kinase domain mutations are early events in the pathogenesis of lung adenocarcinomas, we tested for the presence of EGFR mutations in histologically normal bronchial and bronchiolar epithelia from lung adenocarcinomas bearing the common EGFR mutations. DNA was extracted from microdissected tissue obtained from 21 tumors with known EGFR mutations, 16 tumors without mutation, and...
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