Article
A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.
The Journal of clinical investigation - 15 Oct 1997
Vincent M, Samani N J, Gauguier D, Thompson J R, Lathrop G M, Sassard J
Abstract excerpt
In a backcross population (n = 281) derived from a cross of the Lyon hypertensive rat with Lyon normotensive rat, we investigated whether genetic factors influence the acute cardiovascular responses to pharmacological modulation of the renin-angiotensin system, the sympathetic nervous system, and...
Topics
- Animals
- Blood Pressure
- Calcium Channel Blockers
- Calcium Channels
- Calcium Channels, L-Type
- Chromosome Mapping
- Crosses, Genetic
- Diastole
- Disease Models, Animal
- Female
- Hypertension
- Lod Score
- Male
- Microsatellite Repeats
- Nifedipine
- Phenotype
- Quantitative Trait, Heritable
- Rats