Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.

doi:10.1038/ng0493-354

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Article

Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.

Nature genetics - 1 Apr 1993

Dubay C, Vincent M, Samani N J, Hilbert P, Kaiser M A, Beressi J P, Kotelevtsev Y, Beckmann J S, Soubrier F, Sassard J

Abstract excerpt

Several genetic loci involved in blood pressure regulation have recently been localized in experimental models of hypertension, but the manner in which they influence blood pressure remains unknown. Here, we report a study of the Lyon hypertensive rat strain showing that different loci are involved in the regulation of steady-state (diastolic pressure) and pulsatile (systolic-diastolic, or pulse pressure)...

Topics

Analysis of Variance
Animals
Base Sequence
Blood Pressure
Carboxypeptidase B
Carboxypeptidases
Chromosome Mapping
Crosses, Genetic
DNA Primers
DNA, Satellite
Diastole

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genetic Linkage

Genotype

Hypertension

Male

Molecular Sequence Data

Phenotype

Source

Open in PubMed

Identifiers

PMID: 7981757
DOI: 10.1038/ng0493-354

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7981757-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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