Article
Genetic susceptibility to tobacco carcinogenesis.
Cancer investigation - 1 Jan 1999
Spitz M R, Wei Q, Li G, Wu X
Abstract excerpt
Lung cancer risk is thus defined by the balance between metabolic activation and detoxification of xenobiotic compounds and by the efficiency of DNA repair. It is most likely that multiple susceptibility factors must be accounted for to represent the true dimensions of gene-environment interactions. The ability to identify smokers with the highest risks of developing cancer has substantial preventive...
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